ASV benefits for CSA patients

Who is ASV* therapy suitable for?

Any patient with Left Ventricular Ejection Fraction (LVEF) >45% is eligible for ASV.^1,2,3,4

We can confirm that the observed mortality risk in the SERVE-HF study occurs in patients with LVEF ≤45% and that the harmful effects of ASV correlate with pre-existing LV systolic impairment.⁵

Reduced LVEF should be excluded before starting ASV.¹ Before using ASV, it is important to ensure that LVEF is > 45%. Echocardiography is recommended for this purpose.

Experts statements^1,2,3,4and healthcare authorities agree that patients with LVEF >45% remain eligible for ASV when there is a clinical rationale for using it. ASV is eligible in these different situations: ^1,2,3,4

Heart failure with preserved ejection fraction
CSA associated with long-term opioid therapy without alveolar hypoventilation
Idiopathic CSA or Cheyne-Stokes Respiration
Complex/Emergent/Resistant CSA
CSA after ischemic stroke.

Since May 2015, the French and German healthcare authorities have agreed to limit the contra-indication to heart failure with reduced EF ≤45%.⁴

Find out more about the ResMed device that delivers ASV therapy: AirCurve 10 CS PaceWave

ASV better than CPAP at controlling respiratory events in patients with CompSA

In an intention-to-treat analysis, success (apnoea hypopnoea index [AHI] < 10) at 90 days of therapy was achieved in 89.7% of patients treated with ASV versus 64.5% of participants treated with CPAP.⁶

[N = 66, prospective randomised trial]

asv-benefits-controlling-respiratory-events-ResMed-1-e1567091376697

ASV decreases residual sleepiness after APAP therapy in patients with mixed sleep apnea

After 30 days of APAP treatment, ASV provided a further reduction (compared to baseline) of 12.9% in AHI, 48.5% in central sleep apnoea index (CSAI), 26.1% in micro-arousal index (MAI), and 37.9% in Epworth Sleepiness Scale (ESS) score at similar mean pressure.⁷

[N = 42, sequential study]

asv-benefits-decreasing-residual-sleepiness-ResMed-1-e1567091543876

ASV better than bi-level ST at reducing respiratory events in opioid-induced CSA

In opioid-induced CSA, ASV therapy reduced AHI by 84.7%, central apnoea index (CAI) by 95.7%, Apnoea Index (AI) by 96.4%, and respiratory arousal index (RAI) by 77.1% when compared to bi-level ST. Respiratory parameters were normalised in 83.3% of patients on ASVAuto but only 33.3% of patients on bi-level ST.⁸

[N = 18, prospective, randomised crossover polysomnography study]

asv-benefits-for-opioid-induced-csa-ResMed-1-e1567408213968

ASV improves AHI and ESS in post-acute ischemic stroke patients

ASV therapy improved outcomes for post-acute ischemic stroke patients with CSA, reducing AHI by 81.8% and ESS by 35.6%.⁹

[N = 15, single centre retrospective analysis]

asv-benefits-post-acute-ischemic-stroke-ResMed-1-e1567408270676

ASV improves cardiac output and prognosis in heart failure with preserved ejection fraction*

Prospective randomised and observational heart failure studies (already presented and shortly to be published) have suggested that ASV may be beneficial in heart failure patients with preserved ejection fraction and in those who have CSA with coexisting obstructive sleep apnoea.¹⁰Currently there is no evidence that these patients would be at any risk of harm from ASV therapy.